For the past three years, astronomers at the California Institute of Technology's Palomar Observatory in Southern California have been using the High Performance Wireless Research and Education Network (HPWREN) as the data transfer cyberinfrastructure to further our understanding of the universe. Recent applications include the study of some of the most cataclysmic explosions in the universe, the hunt for extrasolar planets, and the discovery of our solar system's tenth planet. The data for all this research is transferred via HPWREN from the remote mountain observatory to college campuses hundreds of miles away.